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4-acetoxy DMT (hydrochloride)

4-acetoxy DMT (Psilacetin) Analytical Reference Standard, 1mg

WARNING This product is intended for calibrating analytical instrumentation, not for human or veterinary use.

Item No. 14056

4-acetoxy DMT (hydrochloride) (4-acetoxy-N,N-Dimethyltryptamine, O-Acetylpsilocin, Psilacetin, CAS Number: 2748484-99-1)

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Buy 4-AcO-DMT Online. 4-Acetoxy-N, N-dimethyltryptamine (also known as 4-AcO-DMT4-Acetoxy-DMTO-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class. It is a structural analog of psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). Like psilocybin, it is thought to produce its effects primarily by binding to serotonin receptors in the brain; however, the precise mechanism is not fully understood.

O-Acetylpsilocin is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
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4-acetoxy DMT (Psilacetin) Analytical Reference Standard, 1mg


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To begin with,  4 aco dmt for sale and 4 aco dmt buy – O-Acetylpsilocin is a semi-synthetic psychoactive drug (also known as psilacetin, 4-acetoxy-DMT, or 4-AcO DMT) proposed by David Nichols. Then, for pharmacological research, it would be a potentially beneficial alternative to psilocybin. But they are also expected to be prodrugs for psilocin then.

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This occurs as a crystalline-looking white or beige powder, without specific adhesion (sometimes dark). Some manufacturers also market this powder in capsule form, more infrequently in vials. The most prevalent nowadays are synthetic / semi-synthetic tryptamines, while the use of these substances is still limited.

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It is widely used as salt fumarate containing, on average, 1 mg of pure 4-AcO-DMT per 1,24 mg of powder (4-AcO-DMT fumarate). Or, if it is hydrochloride salt, it will, on average, contain 1 mg of pure salt for every 1.15 mg of powder. The difference may simply be marginal, but it’s worth learning.

  • (according to Erowid) Oral dosage (approximate)
  • Effect Threshold: 5-10 mg
  • Low: from 10 to 20 mg
  • Common: from 20 to 30 mg
  • Reliable: 30-50 + mg

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Surprisingly, the molecule’s effects are similar to those of magic mushrooms, such as the genus psilocybe. Of this very thing, the adage is descriptive. Depending on the dosage and the patient, the average length of the trip is around 3 to 6 hours.

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As with psilocine, the relative toxicity of 4-AcO-DMT and, more specifically, neurologically, is a fortiori low: nearly no neurotoxicity. However, these are just exaggerations, and the fact is that no substantial scientific research on the subject has been carried out.

Physical risks, including vomiting, loss of consciousness, and seizures, are especially apparent, but these are fairly rare. Nobody has died from taking it, as far as we know, nor is it likely to be physically dangerous for most individuals.

Pregnant or breastfeeding women or those vulnerable to seizures should certainly be prevented, as with other psychedelics. Basically, heart attacks, blood pressure problems, or mental health issues, such as intense anxiety. If only to err on the side of caution, given the lack of clinical trials.

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4-acetoxy DMT is O-acetylated psilocin that is believed to be a synthetic prodrug of psilocin, the psychedelic hallucinogen derived from various mushrooms.1 Although its pharmacological and toxicological properties are not well known, its activity has been proposed to be somewhat similar to that of psilocybin and psilocin.1 This product is intended for forensic and research applications.

What Is 4-ACO-DMT, And Is It Legal?

4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT4-Acetoxy-DMTO-Acetylpsilocinpsilacetin, and “synthetic mushrooms”) is a novel lesser-known psychedelic substance of the tryptamine class. It is structurally related to psilocybin and psilocin, the active ingredient in psilocybin mushrooms (“magic mushrooms”). 4-AcO-DMT is thought to produce its effects by binding to serotonin receptors in the brain; however, the precise mechanism is not known.

4-AcO-DMT (4-Acetoxy-N,N-dimethyltryptamine) is a synthetic psychedelic compound. People often refer to it as “synthetic mushrooms” due to it producing subjective effects nearly identical to those of psilocybin mushrooms. 4-AcO-DMT’s chemical structure is also similar to that of psilocin, the psychoactive compound that psilocybin turns into when processed by the body.

As a novel psychoactive compound, 4-AcO-DMT exists in a legal grey area in many countries. In some countries, the substance is legal while in others it is explicitly illegal.

This guide will explore various aspects of 4-AcO-DMT, including its chemistry, pharmacology, history, and effects. We will then look at the legal status of 4-AcO-DMT across the world.

What Is 4-AcO-DMT?

4-AcO-DMT is a tryptamine psychedelic, meaning it has the basic element of tryptamine known as the indole structure. Tryptamine itself is a compound that exists throughout nature. It is derived from the essential amino acid tryptophan.

Other tryptamine psychedelics include psilocybin, psilocin, ibogaine, bufotenin, DMT, and 5-MeO-DMT.

4-AcO-DMT is not found in nature. The drug can only be made in a lab.

How 4-AcO-DMT Causes A Psychedelic Experience

4-AcO-DMT is a structural analog of the psychedelic compound psilocybin, meaning they both have a similar chemical structure.

Like psilocybin, it is thought that 4-AcO-DMT acts as a prodrug to psilocin, meaning that when the body processes it, it breaks down into psilocin, which is responsible for magic mushrooms’ subjective effects. The psychedelic researcher David E. Nichols suggested this in 1999.

We don’t know how the body metabolizes 4-AcO-DMT. However, based on the chemistry and metabolism of similar tryptamines, it is reasonable to assume that this substance undergoes deacetylation in the body (where an acetyl group is removed from the molecule), forming psilocin.

From that point on, the psilocin would then bind to the serotonin 5-HT2A receptors in the brain. This results in psychedelic effects that many people find indistinguishable from those caused by shrooms.

It may be possible, nonetheless, that 4-AcO-DMT is psychoactive on its own. If so, when you ingest the compound, it would bind to serotonin receptors, including 5-HT2A receptors, eliciting a psychedelic effect. And this effect may be unique, and different from psilocin in some way. Indeed, some users report that the 4-AcO-DMT experience is not exactly the same as the psilocybin experience.

In 1963, chemists Albert Hofmann and Franz Troxler patented their discovery of 4-AcO-DMT along with other indole esters they had synthesized.1 Just as Hofmann put LSD aside for five years after synthesizing it in 1938, unaware of its psychedelic properties, psilacetin was patented but shelved. According to the United Nations Office on Drugs and Crime, synthetic tryptamines like psilacetin began appearing in illicit drug markets throughout the 1990s.2

The Chemistry of 4-AcO-DMT

Psilacetin is a structural analog of the psychedelic mushroom (aka psilocybin mushroom or magic mushroom) compound psilocybin. Psilocybin is a prodrug of psilocin, and psilocin is an analog of the neurotransmitter of serotonin. Chemically, psilacetin is O-acetylated psilocin, whereas psilocybin is O-phosphorylated.

The Pharmacology of 4-AcO-DMT

In their 1963 patent, Hofmann and Troxler described indole acetate esters like 4-AcO-DMT as serotonin receptor antagonists.1 However, over the years, scientists have come to classify them as prodrugs that are inactive on their own by way of analogy to psilocybin.

The way psilacetin is metabolized in the human body is unknown. However, based on the chemistry and metabolism of similar tryptamine compounds,3 it is reasonable to assume that psilacetin undergoes deacetylation to form psilocin. From that point, psilocin would follow the accepted theory of binding to the serotonin 5-HT2A receptor, causing a psychedelic effect.4

There are no published scientific studies specifically addressing whether psilacetin is metabolically active on its own. The possibility exists that when ingested, psilacetin may bind to serotonin receptors, including 5-HT2A, and elicit a psychedelic effect, perhaps one that is unique from psilocin. According to anecdotal reports, the psychoactivity of psilacetin is immediate when in injected, bypassing the first-pass metabolism in the stomach and liver.5

A 2017 substance abuse study using rodents suggests a single administration of 4-AcO-DMT prevents and reverses heroin and nicotine addictions.6 The authors of the study theorize the mechanism involves preventing the up-regulation of brain-derived neurotrophic factor via serotonin 5-HT2A receptor signaling.

The renowned psychedelic researcher Dr. David Nichols has suggested that psilacetin, like psilocybin, is a prodrug of psilocin.7 In their 1999 work, Dr. Nichols and Dr. Stewart Frescas synthesized the fumarate salt of psilacetin.

Recent Scientific Studies on 4-AcO-DMT

Following 20 years of inactivity, the chemical community recently published new data about psilacetin. Building on the work Nichols and Frescas did in 1999 scientists solved the crystal structure of 4-AcO-DMT fumarate in March 2019.8 Chadeayne, et al. demonstrated that the solid-state structure is an asymmetric unit containing one 4-acetoxy-N,N-dimethyltryptammonium cation, and one 3-carboxyacrylate anion. Despite its use as a research chemical in the illicit drug market, this work was the first conclusive structural characterization of the molecule.

In a follow-up to this study, the same research team defined the crystal structure of a new solvate form of 4-AcO-DMT fumarate, bis(4-acetoxy-N,N-dimethyltryptammonium) fumarate.9 The crystal structure consists of two protonated psilacetin molecules that are charge-balanced by one fumarate dianion. This new solvate form of psilacetin is an important discovery because it opens the door to more options for drug development.

  • 4-acetoxy-N,N-Dimethyltryptamine
  • O-Acetylpsilocin
  • Psilacetin
Technical Information
Formal Name: 3-[2-(dimethylamino)ethyl]-1H-indol-4-ol-4-acetate, monohydrochloride
CAS Number: 2748484-99-1
Molecular Formula : C14H18N2O2 • HCl
Formula Weight : 282.8
Purity : ≥90%
A solution in acetonitrile
  • DMF: 30 mg/ml
  • DMSO: 10 mg/ml
  • Ethanol: 20 mg/ml
  • PBS (pH 7.2): 10 mg/ml
λmax: 219, 277 nm
InChi Code: InChI=1S/C14H18N2O2.ClH/c1-10(17)18-13-6-4-5-12-14(13)11(9-15-12)7-8-16(2)3;/h4-6,9,15H,7-8H2,1-3H3;1H
Shipping & Storage Information
Storage: -20°C
Shipping: Wet ice in the continental US; may vary elsewhere
Stability: ≥ 2 years

4-AcO-DMT was first synthesized in 1963 by Albert Hofmann and Franz Troxler as part of a chemical investigation into psilocin analogs. However, it was not tested for psychoactivity during this time. It is unknown when it was first explored in humans. A paper authored by David E. Nichols in 1999 proposed its potential use as an alternative to psilocybin for pharmacological research due to the lower cost of synthesis.[2] Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s.[citation needed]

Subjective effects include geometric visual effects, time distortion, enhanced introspection, euphoria, and ego loss. 4-AcO-DMT’s effects are considered to be nearly identical to psilocybin, with some subtle differences. It has been theorized to act as a prodrug to psilocin in a manner similar to psilocybin, which may account for this similarity. 4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile have led it to become popular among novel psychoactive substance users who seek mystical or entheogenic experiences. It is occasionally sold in capsules or pressed pills and marketed as “synthetic shrooms”.

Very little data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT. Although its toxicity profile is believed to be near-identical with psilocybin mushrooms (see this section), which are known to be physiologically non-toxic, there is no hard data to support this claim. It is highly advised to use harm-reduction practices if using this substance.

The Effects Of 4-AcO-DMT

As already mentioned, the effects of 4-AcO-DMT are similar (if not the same) as those induced by a mushroom trip experience.

Physical Effects

  • Sedation
  • Body feeling heavy
  • A body high characterized by a pleasurable, warm, soft tingling sensation
  • Tactile enhancement
  • Nausea
  • Excessive yawning
  • Pupil dilation

Visual Effects

  • Color enhancement
  • Objects appear to melt, flow, breathe, and morph
  • Color shifting (objects change colors)
  • Tracers (these are trails left behind moving objects, similar to those found in long exposure photography)
  • After images (visual perceptions which continue to appear in your vision after the exposure to the original image has ceased. For example, when moving your hand in front of your face, you may see an after image of your hand left behind)
  • Perspective distortions
  • The perception of geometric patterns
  • Internal visions: with eyes closed, you can perceive entities, landscapes, scenarios, and plots
  • External hallucinations

Auditory Effects

  • Enhancement
  • Distortion
  • Auditory hallucinations

Cognitive Effects

  • Novelty enhancement (a feeling of increased fascination, awe, and appreciation in relation to one’s external environment)
  • Creativity enhancement
  • Increased sense of humor
  • Thought loops (becoming trapped within a chain of thoughts, repeating itself over and over again)

Emotional Effects

  • Experiencing emotions more intensely
  • Swinging between different emotional states
  • Euphoria
  • Joy
  • Awe
  • Peacefulness
  • Contentment
  • Compassion
  • Anxiety
  • Fear

Mystical Effects

  • Ego dissolution
  • A sense of oneness or interconnectedness, perhaps the feeling of becoming one with the universe
  • A sense of the experience being sacred or holy
  • Encountering the “divine”
  • An experience of eternity or infinity
  • The feeling that the experience takes place outside of space and time
  • Ecstasy and bliss
  • Ineffability: being unable to adequately put the experience into words

Differences Between 4-Aco-DMT And Psilocybin

Despite many people claiming 4-AcO-DMT offers an identical experience to psilocybin mushrooms, others say there are differences between the two. And this could come down to the fact that these mushrooms contain other psychoactive compounds, not just psilocybin. Indeed, consuming magic mushrooms is very different from ingesting pure psilocybin by itself (which occurs pretty much exclusively in clinical trials).

The other psychoactive chemicals in magic mushrooms (baeocystin, norbaeocystin, norpsilocin, and aeruginascin) work together to produce the overall psychedelic experience.

For example, researchers have found that aeruginascin seems to modify the pharmacological action of psilocybin, contributing to a euphoric mood during the experience.

In the world of cannabis, this synergy is known as the entourage effect. Researchers have proposed that compounds in cannabis other than THC act synergistically with it, altering the subjective and medicinal effects. The various compounds in magic mushrooms may likewise result in an entourage effect.

Compared to magic mushrooms, some users report that 4-AcO-DMT does the following.

  • Lasts a little longer (around seven hours, rather than six)
  • Has a more relaxing quality to it
  • Is more likely to be euphoric, gentle, warm, and colorful
  • Involves a less emotional and visual experience
  • Is less likely to be jarring/scary
  • Has visuals reminiscent of DMT
  • Is less likely to produce nausea (which may be because you don’t have to ingest mushroom matter)

It is possible that these differences could be related to the entourage effect caused by other compounds contained in psilocybin mushrooms.

Nonetheless, it’s important to keep in mind that dosage, set, and setting play significant roles in the quality of psychedelic experiences as well.

The Benefits Of Using 4-AcO-DMT Over Psilocybin

The psychedelic researcher Dr. David Nichols suggested in a 1999 paper that 4-AcO-DMT could be a potentially useful alternative to psilocybin for research due to the lower cost of synthesis.

Many users may find 4-AcO-DMT preferable to psilocybin mushrooms because it’s easier to dose.

With magic mushrooms, you never know how much psilocybin or psilocin a particular batch will contain. Also, within a particular batch, some individual mushrooms may be more potent than others. This can result in unreliable dosing.

On the other hand, 4-AcO-DMT can weigh the precise dose a person wants. This would apply to pure psilocybin, too, but this is not really available unless you take part in a clinical trial.

Is 4-AcO-DMT Safe?

There is a lack of research on 4-AcO-DMT. There are no studies on the toxicity and long-term health effects of the substance. The exact toxic dose is also unknown. This is because 4-AcO-DMT is a research chemical with a very short history of human use.

People assume 4-AcO-DMT has a similar safety profile as psilocybin due to their chemical similarity, but there is no existing data to support this claim.

RELATEDWhere Are Psychedelics Legal Around the Globe? Here’s Everything You Need To Know

The legal status of 4-AcO-DMT is often ambiguous. Although the drug is federally unscheduled in the United States, manufacturing, distributing, or possessing the compound for human consumption violates the Federal Analogue Act. Nonetheless, prosecutions involving the substance are pretty much unheard of.

In the United Kingdom, since 4-AcO-DMT is an ester of psilocin, it’s a Class A substance by default under the Misuse of Drugs Act 1971. This means it potentially carries the harshest drug crime sentences. As a psychoactive substance, 4-AcO-DMT is also prohibited under the UK’s Psychoactive Substances Act 2016.

As an ester of psilocin, 4-AcO-DMT is similarly illegal by default in many other countries, including Australia, New Zealand, Germany, Italy, and Switzerland. 4-AcO-DMT is also a controlled substance in Brazil, Sweden, and Turkey.

However, the substance is legal in a number of other countries, including Canada, where many 4-AcO-DMT vendors are based.

What To Consider Before Trying 4-AcO-DMT

If you are thinking of taking 4-AcO-DMT, you should be aware that you may be taking an illegal substance. Moreover, since this substance does not have a long history of use like magic mushrooms, we don’t yet know its safety profile. Having said that, many users have used 4-AcO-DMT with no known ill effects.

As when using any other psychedelic, it’s important to pay attention to your dosage, set (what you are mentally bringing to the experience), and setting (where you have the experience and who you trip with).

Despite being a pure synthetic compound and not chemically identical to psilocybin, many people find that 4-AcO-DMT offers a trip that is more or less the same as a magic mushroom experience. It is possible to have a deep, profound, and transformative experience with 4-AcO-DMT. And since Nichols has suggested this drug could be used as an alternative to psilocybin, due to it breaking down into psilocin, 4-AcO-DMT also has the potential to treat the same mental health issues that psilocybin can treat, such as depression.

Finally, the differences between 4-AcO-DMT and psilocybin mushrooms highlight an exciting area of research: how the other compounds in shrooms may contribute to the overall psychedelic experience.

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