Buy 5-MeO-DMT Online
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5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety
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5-MeO-DMT is a powerful, hallucinogenic tryptamine found in various plants and used historically in the preparation of psychotropic snuffs. This certified solution standard is suitable for 5-MeO-DMT testing methods by GC/MS or LC/MS in clinical toxicology, urine drug testing, or forensic analysis applications.
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THE ULTIMATE GUIDE TO
A recent epidemiological study suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used for spiritual and recreational reasons is associated with subjective improvement in depression and anxiety. Further exploration of the potential psychotherapeutic effects of 5-MeO-DMT could inform future clinical trials. Objectives: We examined self-reported improvement in depression and anxiety among people who use 5-MeO-DMT in a group setting with structured procedures guiding dose and administration of 5-MeO-DMT.
Such procedures also include activities for the preparation of, and support during/following sessions, which are similar to procedures used in clinical trials of hallucinogen administration. Next, we examined whether depression or anxiety were improved following use, and whether the acute subjective effects (mystical/challenging) or beliefs about the 5-MeO-DMT experience were associated with improvements in these conditions. Methods: Respondents (n = 362; Mage = 47.7; Male = 55%; White/Caucasian = 84%) completed an anonymous web-based survey.
Results: Of those reporting having been diagnosed with depression (41%) or anxiety (48%), most reported these conditions were improved (depression = 80%; anxiety = 79%) following 5-MeO-DMT use, and fewer reported they were unchanged (depression = 17%; anxiety = 19%) or worsened (depression = 3%; anxiety = 2%). Improvement in depression/anxiety conditions were associated with greater intensity of mystical experiences and higher ratings of the spiritual significance and personal meaning of the 5-MeO-DMT experience.
There were no associations between depression or anxiety improvement and the intensity of acute challenging physical/psychological effects during the 5-MeO-DMT experience. Conclusions: Future prospective controlled clinical pharmacology studies should examine the safety and efficacy of 5-MeO-DMT administration for relieving depression and anxiety.
To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid gland secretions of the toad, Incilius alvarius. Several synthetic routes were initially explored, and the selected process featured an optimized Fischer indole reaction to 5-MeO-DMT freebase in high-yield, from which the 1:1 succinate salt was produced to provide 136 g of crystalline active pharmaceutical ingredient (API) with 99.86% peak area by high-performance liquid chromatography (HPLC) and a net yield of 49%.
The report provides in-process monitoring, validated analytical methods, impurity formation and removal, and solid-state characterization of the API essential for subsequent clinical development.
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5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N, N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced.
In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola Theodora—both of which are traditionally harvested to make psychoactive snuff.
It’s also found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius; aka the Colorado River Toad ), which is native to the southwestern United States and northwestern Mexico. Venom harvesting has put pressure on the population of this ecologically sensitive species. It’s currently listed as imperiled or locally instinct in several states in the US. Seeking out alternative sources of 5-MeO DMT, such as synthetic or plant-derived versions, is strongly recommended.
In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders.
While research into 5-MeO-DMT is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks when a follow-up assessment was completed.
These results support the findings of a survey of 362 people who had taken 5-MeO-DMT. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.
5-MeO-DMT has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practitioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.
5-MeO-DMT is one of the most potent psychedelics you can consume, and the experience can be intense and powerful—in both positive and negative ways. Though everyone will undergo a unique and individual experience, there are some general things you can expect.
What to Expect
Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taking synthetic 5-MeO-DMT, a threshold dose is around 1-2 mg, while a standard full dose is 8-12 mg. When naturally derived, the threshold dose is 5-10 mg and a standard full dose is 30-60 mg.
The effects of 5-MeO-DMT come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.
One of the most common features of the 5-MeO-DMT experience is the enhancement of tactile awareness, which can reach the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria. During the onset, anxiety or excitement is often felt. It’s also common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while simultaneously experiencing the totality of both. Ego death is also typical of the 5-MeO-DMT experience. Other effects include auditory hallucinations, time distortion, nausea, and memory loss.
Like the other tryptamines, 5-MeO-DMT has the same basic structure as DMT but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter. Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function.
There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined. Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine. These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.
Some other safety concerns have been flagged by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary grass) caused fatal tachycardia and respiratory failure. Although more likely due to other toxins in the plant, this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources.
5-MeO-DMT doses are different depending on whether the substance is synthetic or naturally derived.
Small: 3-6 mg
Medium: 6-10 mg
Large: 11-15+ mg
Small: 10-20 mg
Medium: 20-40 mg
Large: 40-60+ mg
BENEFITS & RISK
5-MeO-DMT has been used as a healing agent by South American shamans for thousands of years, partially due to its ability to occasion mystical-type experiences. While research into the drug is still limited, recent studies are backing up these ancient claims.
In a survey of 362 adults, 80% of respondents reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. More than that, improvements were directly related to the intensity of the mystical effects felt during the experience. Respondents that had intense mystical experiences also reported higher rates of the experience’s personal meaning and spiritual significance.
The benefits of 5-MeO-DMT have also proven to be enduring—in a recent preliminary study, 42 participants who took 5-MeO-DMT reported an increase in levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks after the initial experience when a follow-up assessment was completed.
One of the unique aspects of 5-MeO-DMT is the short duration of the experience compared to more common psychedelics, such as LSD and psilocybin. While research has shown that psychedelic-assisted psychotherapy can help people with a variety of psychological disorders, these sessions often require a 7 to 8-hour session. Because 5-MeO-DMT is short-acting and lasts just 30-90 minutes, it shows promise as an accompaniment to therapy sessions, which are typically 60 to 90 minutes.